Serum Lipid Profile Changes After Bariatric Surgery

Abstract

Background: Obesityisaccompaniedbyanumberof comorbiditiesthatgravelylowerpatients’ qualityof life;onesuchcomorbid-ityisserumlipidabnormalities. Studieshaveshownthatweightlossdecreasesserumtotalcholesterolandlow-densitylipoprotein (LDL) cholesterol and increases high-density lipoprotein (HDL) cholesterol. Bariatric surgery is one of the most recent ways to treat obesity and manage weight loss in overweight patients whose options for weight loss are limited. Objectives: Theaimof thisstudywastoassesstheeffectof bariatricsurgeryonlipidprofileof surgicalcandidatesduringthethree months of post-operative care. Methods: This prospective study was performed among 36 obese candidates of bariatric surgery at Mostafa Khomeini Hospital in Tehran, Iran from April to September of 2012. Body mass index (BMI), serum cholesterol, triglyceride, HDL and LDL levels were measured before and three months following the surgical intervention. Results: The mean age of the participants was 35.39 ± 10.32 years. Mean body mass index (BMI) of the patients before surgery was 46.74 ± 6.71 kg/m 2 , which was lowered to 38.24 ± 5.31 kg/m 2 after the intervention. Assessments showed a statistically significant increaseintheserumlevelof HDLandastatisticallysignificantdecreaseintheserumlevelof triglycerides,butnosignificantchange in the serum level of cholesterol or LDL was noted. Moreover, results showed a positive correlation between serum LDL variations and changes in BMI. Conclusions: Our findings showed that bariatric surgery improves weight loss and can help with managing or treating co-morbid illnesses through reducing triglyceride level and increasing HDL level, both of which improve patients’ long-term cardiac, hepatic and endocrine health status. Diet therapy, physical activity (aerobic primarily), behav-ioral therapy (e.g., treating underlying psychological en-ablers of eating disorders), pharmacotherapy and at last resort, surgical intervention (9). Indications for bariatric surgery include morbid obesity (a BMI higher than 40 kg/m 2 ) and severe obesity (BMI = 35 - 40 kg/m 2 ) in a patient (10).