Antimicrobial and anticancer activities of bisacodyl and it’s deacetylated metabolite DDPM

Proceedings of MOL2NET 2018, International Conference on Multidisciplinary Sciences, 4th edition Pub Date : 2019-01-11 DOI:10.3390/MOL2NET-04-06130

A. Fatma, Ricco Christophe, E. Mehdi, S. Maité, Ben Ali Mamdouh, F.G.D.A. Clotilde

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Abstract

The antibacterial activity of bisacodyl and its deacetylated metabolite, DDPM was investigated against Gram-positive pathogens including Staphylococcus aureus (ATCC 9144), Micrococcus luteus (LB14110), Salmonella enterica (NCTC 6017) with minimal inhibitory concentration (MIC) ranging from 12.5 to 25 μg/mL, 6.25 to 12.5 μg/mL and 25 to 50 μg/mL respectively. The results of antibacterial activity against Gram-negative foodborne Pseudomonas aeruginosa (ATCC 9027), Escherichia coli (ATCC 8739), show MIC values between 12.5-25 μg/mL and 25-50 μg/mL. The antifungal activity was also evaluated against the opportunistic pathogenic yeast Candida albicans (ATCC 2091) with MIC ranging from 12.5 to 25 μg/mL. Furthermore, the anticancer activity was evaluated against epithelial cervical cancer cell line (ATCC, Manassas,VA, USA). The results obtained indicated that bisacodyl and its deacetylated metabolite, DDPM have a cytotoxic activity at 63.69 μg/mL and 16.7 μg/mL respectively.

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bisacodyl及其去乙酰化代谢物DDPM的抗菌和抗癌活性

研究了双草酰及其去乙酰化代谢物DDPM对革兰氏阳性病原菌金黄色葡萄球菌(ATCC 9144)、黄体微球菌(LB14110)、肠炎沙门氏菌(NCTC 6017)的抑菌活性，最小抑菌浓度(MIC)分别为12.5 ~ 25 μg/mL、6.25 ~ 12.5 μg/mL和25 ~ 50 μg/mL。对革兰氏阴性食源性铜绿假单胞菌(ATCC 9027)和大肠杆菌(ATCC 8739)的抑菌活性MIC值在12.5 ~ 25 μg/mL和25 ~ 50 μg/mL之间。对MIC为12.5 ~ 25 μg/mL的条件致病性白色念珠菌(ATCC 2091)进行了抑菌活性评价。此外，对上皮性宫颈癌细胞系(ATCC, Manassas,VA, USA)的抗癌活性进行了评估。结果表明，比沙草酰及其去乙酰化代谢物DDPM的细胞毒活性分别为63.69 μg/mL和16.7 μg/mL。

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Proceedings of MOL2NET 2018, International Conference on Multidisciplinary Sciences, 4th edition

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