{"title":"Electrophysiological aspects of 5-HT receptor-mediated adenylyl cyclase activation","authors":"P.M. Larkman","doi":"10.1016/1044-5765(95)90002-0","DOIUrl":null,"url":null,"abstract":"<div><p>Stimulation of adenylyl cyclase by 5-hydroxytryptamine increases the excitability of central neurones through several ionic mechanisms. Prominent among these is enhancement of the hyperpolarization-activated inward rectifier, I<sub>lv</sub> and inhibition of a calcium-sensitive potassium current responsible for the slow afterhyperpolarization following action potential discharge. Increased excitability results from a small depolarization coupled with more subtle effects on the integrative properties of neurones. Interestingly, pharmacologically distinct 5-HT receptors mediate these responses. In addition, the mechanisms by which cAMP modulates the target ion channels may also be different.</p></div>","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"7 6","pages":"Pages 383-393"},"PeriodicalIF":0.0000,"publicationDate":"1995-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/1044-5765(95)90002-0","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in Neuroscience","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/1044576595900020","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
Stimulation of adenylyl cyclase by 5-hydroxytryptamine increases the excitability of central neurones through several ionic mechanisms. Prominent among these is enhancement of the hyperpolarization-activated inward rectifier, Ilv and inhibition of a calcium-sensitive potassium current responsible for the slow afterhyperpolarization following action potential discharge. Increased excitability results from a small depolarization coupled with more subtle effects on the integrative properties of neurones. Interestingly, pharmacologically distinct 5-HT receptors mediate these responses. In addition, the mechanisms by which cAMP modulates the target ion channels may also be different.
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