Ophthalmological profile of patients with thyroid diseases in Fortaleza, Ceará, Brazil: glaucoma investigation

Bianca Diogo Lessa Castro, Sandy Ester Freire Sobral, Pedro Henrique Marques Pereira, Aline Lourenço Cordeiro, Sarah Dibe Santos, Ana Adélia Sá Costa, Herculano Pontes Barros Ribeiro, Hissa Tavares de Lima Gradvohl, Laura Da Silva Girão Lopes, J. Ferreira
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引用次数: 1

Abstract

Objetivo: avaliar a prevalência de glaucoma entre os portadores de patologias tireoidianas, acompanhados na Clínica Escola de Saúde (CES) do núcleo de Medicina do Centro Universitário Christus (UNICHRISTUS), Fortaleza – Ceará – Brazil. Métodos: estudo transversal e descritivo de prontuários de pacientes diagnosticados com hipotireoidismo ou hipertiroidismo pelo Código Internacional de Doenças (CID-10) no sistema eletrônico da CES, entre 2013 e 2018. Pacientes triados foram convidados a realizar um exame oftalmológico na Fundação Leiria de Andrade (FLA). Resultados: dos 499 prontuários triados, 22,8% (114) possuíam diagnóstico confirmado para tireoidopatias, sendo 85,9% (98) com hipotireoidismo, e 14,0% (16) com hipertireoidismo. Desses, 72,0% (101) eram mulheres e 28,0% (13) homens. A faixa etária mais prevalente foi entre 41 a 60 anos de idade, correspondendo a 46,4% (53), sendo 65,7% (75) de Fortaleza – Ceará – Brasil. As principais comorbidades associadas às tireoidopatias foram hipertensão arterial sistêmica, representando 43,8% (50), seguida de dislipidemia, 26,3% (30) e diabetes mellitus tipo 2 em 13,1% dos pacientes (15). Do total, 25 pacientes foram encaminhados à FLA, 84,0% (21) relataram doenças oculares prévias, 4,0% (1) diagnosticado com escavação aumentada constitucional e 12,0% (3) com diagnóstico de glaucoma primário de ângulo aberto. Conclusão: apesar da hipótese de associação entre o glaucoma e as tireoidopatias, o tamanho amostral não possibilitou inferências sobre o risco aumentado de sua correlação, assim como em outros estudos preexistentes na literatura, sendo necessários mais estudos para elucidar com maior precisão essa associação relevante. Palavras-chave: Glaucoma; Tireoide; Hipotireoidismo; Hipertireoidismo; Pressão Intraocular. Resumo Objective: To evaluate the prevalence of ophthalmological pathologies, between thyroidopathies, for early diagnosis of glaucoma in patients seen at the Clínica Escola de Saúde (CES) of the Medicine Center of the Centro Universitário Christus (UNICHRISTUS), Fortaleza – Ceará – Brazil. Methods: A cross-sectional study and descriptive analysis of medical records of patients diagnosed with hypothyroidism or hyperthyroidism by the International Classification of Diseases (ICD-10) on the CES electronic system, between 2013 and 2018. Screened patients were invited to perform an eye examination at Fundação Leiria de Andrade (FLA). Results: Of the 499 medical records screened, 22.8% (114) had a confirmed diagnosis for thyroid disorders, 85.9% (98) with hypothyroidism, and 14.0% (16) with hyperthyroidism. Of these, 72.0% (101) were women and 28.0% (13) men. The most prevalent age group was between 41 and 60 years old, corresponding to 46.4% (53), being 65.7% (75) from Fortaleza Ceará. The main comorbidities associated with thyroid diseases were systemic arterial hypertension, 43.8% (50), followed by dyslipidemia, 26.3% (30), and type 2 diabetes mellitus in 13.1% of patients (15). Of the total, 25 patients were referred to the FLA, 84.0% (21) reported previous eye diseases, 4.0% (1) diagnosticated with increased constitutional excavation, and 12.0% (3) with a diagnosis of primary open-angle glaucoma. Conclusion: Despite the hypothesis of an association between glaucoma and thyroidopathy, the sample size didn’t allow inferences about the increased risk of its correlation, as well as in other pre-existing studies in the literature, requiring further studies to elucidate this relevant association.
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巴西塞埃尔福塔莱萨甲状腺疾病患者的眼科概况:青光眼调查
目的:评估在巴西福塔莱萨大学基督中心(UNICHRISTUS)医学中心的Escola de saude (CES)诊所随访的甲状腺疾病患者中青光眼的患病率。方法:对2013年至2018年在CES电子系统中根据国际疾病代码(icd -10)诊断为甲状腺功能减退或甲状腺机能亢进的患者的医疗记录进行横断面和描述性研究。被筛选的患者被邀请在fundacao Leiria de Andrade (FLA)进行眼科检查。结果:在499份筛选的医疗记录中,22.8%(114)确诊为甲状腺疾病,85.9%(98)确诊为甲状腺功能减退,14.0%(16)确诊为甲状腺功能亢进。其中72.0%(101)为女性,28.0%(13)为男性。最普遍的年龄组在41 - 60岁之间,对应46.4%(53),其中65.7%(75)来自福塔莱萨- ceara -巴西。甲状腺疾病的主要合并症为全身性动脉高血压(43.8%(50)),其次为血脂异常(26.3%(30))和2型糖尿病(13.1%(15))。25例患者被转介到FLA, 84.0%(21例)报告既往眼病,4.0%(1例)诊断为体质凹陷增加,12.0%(3例)诊断为原发性开角型青光眼。结论:尽管青光眼和甲状腺疾病之间存在关联的假设,但样本量并不能像文献中其他现有研究那样推断其相关性的风险增加,需要更多的研究来更准确地阐明这种关联。关键词:青光眼;甲状腺;甲状腺功能减退;甲状腺机能亢进症;眼内压。目的:评估在Centro universitario Christus (UNICHRISTUS)医学中心clinica Escola de saude (CES)看到的患者中甲状腺疾病中眼科病理的患病率,用于青光眼的早期诊断,Fortaleza - ceara -巴西。方法:对2013年至2018年CES电子系统上根据国际疾病分类(ICD-10)诊断为甲状腺功能减退或甲状腺机能亢进的患者的医疗记录进行横断面研究和描述性分析。筛查患者被邀请到fundacao Leiria de Andrade (FLA)进行眼科检查。结果:在499份医疗记录中,22.8%(114)确诊为甲状腺疾病,85.9%(98)确诊为甲状腺功能减退,14.0%(16)确诊为甲状腺机能亢进。其中,72.0%(101人)为女性,28.0%(13人)为男性。最流行的年龄群体在41 - 60岁之间,对应46.4%(53岁),65.7%(75岁)来自福塔莱萨ceara。与甲状腺疾病相关的主要合并症为全身性高血压,43.8%(50例),其次为血脂异常,26.3%(30例),13.1%为2型糖尿病(15例)。在所有患者中,25例患者被转介到FLA, 84.0%(21例)报告既往眼病,4.0%(1例)诊断为体质开裂增加,12.0%(3例)诊断为原发性开角型青光眼。结论:尽管青光眼和甲状腺疾病之间存在关联的假设,但样本量不允许像文献中其他已有的研究那样推断其相关性风险增加,需要进一步的研究来阐明这种关联。
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