Preventive Efficacy of Domestic Vaccines against a New Coronavirus Infection in the Immunization of Employees of Medical Organizations

I. V. Feldblum, T. M. Repin, M. Devyatkov, V. Semerikov, M. A. Gileva, A. A. Kovtun, N. Markovich
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Abstract

Relevance. Evaluation of the preventive effectiveness of domestic vaccines in immunization of employees of medical organizations, in the context of the ongoing pandemic caused by the SARS-CoV-2 virus, remains important. The aim. To evaluate the preventive effectiveness of domestic vaccines in the immunization of employees of medical organizations. Materials and methods. The preventive efficacy of domestic vaccines was studied in an epidemiological, analytical, retrospective (historical), cohort, parallel study involving 1115 healthcare workers from various outpatient and policlinic organizations in the city of Perm. Results. The high preventive efficacy of COVID-19 vaccination of health care workers was established in the conditions of analytical cohort study (the incidence of the unvaccinated was 3.3 times higher than the incidence of vaccinated). Among the vaccinated, a milder course of the disease was observed. The GamCovidVac Spuntic V and Sputnik Light vaccines were characterized by the highest prophylactic efficacy for which was 76.1 and 78.2 respectively, against 54.53 with Covivac immunization and 50.7 with EpiVacCorona. Conclusions. Vaccination is an effective measure against COVID-19 and can be recommended in the context of ongoing pandemic.
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国产新型冠状病毒疫苗在医疗机构从业人员免疫中的预防效果
的相关性。在SARS-CoV-2病毒大流行的背景下,评估国产疫苗在医疗机构员工免疫接种中的预防效果仍然很重要。的目标。目的评价国产疫苗在医疗机构职工免疫接种中的预防效果。材料和方法。通过流行病学、分析性、回顾性(历史)、队列、平行研究,对来自彼尔姆市各门诊和门诊机构的1115名医护人员进行了国产疫苗的预防效果研究。在分析队列研究的条件下,建立了医护人员接种COVID-19疫苗的高预防效果(未接种疫苗的发生率是接种疫苗的发生率的3.3倍)。在接种疫苗的人中,观察到疾病的病程较轻。GamCovidVac Spuntic V和Sputnik Light疫苗的预防效果最高,分别为76.1和78.2,而Covivac和EpiVacCorona疫苗的预防效果分别为54.53和50.7。结论。疫苗接种是应对COVID-19的有效措施,可在当前大流行的背景下予以推荐。
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