Acute dehydroepiandrosterone (DHEA) effects on sexual arousal in postmenopausal women.

L. Hackbert, J. Heiman
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引用次数: 83

Abstract

BACKGROUND The age-related decline of dehydroepiandrosterone (DHEA) has prompted research on its experimental replacement in women. Although no relationship to sexual functioning in healthy women has been shown to date, DHEA replacement has potential for affecting sexual response. METHODS To investigate DHEA effects, 16 sexually functional postmenopausal women participated in a randomized, double-blind, crossover protocol in which oral administration of DHEA (300 mg) or placebo occurred 60 minutes before the presentation of an erotic video segment. Blood DHEA sulfate (DHEAS) changes, subjective and physiological sexual responses, as well as affective responses were measured in response to videotaped neutral and erotic video segments. RESULTS The concentration of DHEAS increased 2-5-fold following DHEA administration in all 16 women. Subjective ratings across DHEA and placebo conditions showed significantly greater mental (p < 0.016) and physical (p < 0.036) sexual arousal to the erotic video with DHEA vs. placebo. Positive affect also increased during the erotic video across drug conditions. Vaginal pulse amplitude (VPA) and vaginal blood volume (VBV) demonstrated a significant increase (p < 0.001) between neutral and erotic film segments within both conditions (DHEA and placebo) but did not differentiate drug conditions. CONCLUSION In sum, increases in mental and physical sexual arousal ratings significantly increased in response to an acute dose of DHEA in postmenopausal women.
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急性脱氢表雄酮(DHEA)对绝经后妇女性唤起的影响。
背景脱氢表雄酮(DHEA)与年龄相关的下降促使了对其在女性中的实验性替代研究。虽然到目前为止还没有发现与健康女性性功能的关系,但脱氢表雄酮替代有可能影响性反应。方法:为了研究脱氢表雄酮的作用,16名性功能正常的绝经后妇女参加了一项随机、双盲、交叉试验,在观看色情视频片段前60分钟口服脱氢表雄酮(300毫克)或安慰剂。通过对中性和情色录像片段的反应,测量受试者血液中硫酸脱氢表雄酮(DHEAS)的变化、主观和生理的性反应以及情感反应。结果16名妇女在给予脱氢表雄酮后,脱氢表雄酮浓度增加2-5倍。在DHEA和安慰剂条件下的主观评分显示,与安慰剂相比,DHEA对色情视频的精神(p < 0.016)和身体(p < 0.036)性唤起明显更高。在不同的药物条件下,色情视频中的积极情绪也有所增加。阴道脉冲振幅(VPA)和阴道血容量(VBV)在两种情况下(DHEA和安慰剂)均在中性和色情电影片段之间显着增加(p < 0.001),但在药物条件下没有差异。综上所述,急性剂量的脱氢表雄酮可显著增加绝经后妇女的精神和生理性唤起评分。
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