Tolerance to cytostatic drugs bleomycin and vincristine by white rot fungi

IF 1.4 4区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES Archives of Environmental Protection Pub Date : 2023-04-01 DOI:10.24425/aep.2020.134540
Marcelina Jureczko, W. Przystaś, M. Urbaniak, Anna Banach-Wiśniewska, Łukasz Stępień
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引用次数: 1

Abstract

: Cytostatic drugs have become one of the greatest environmental hazards. They exhibit toxic, carcinogenic, mutagenic and teratogenic eff ects on fl ora and fauna, including people. They are poorly eliminated in conventional wastewater treatment plants and their mixtures could possess higher ecotoxicity than individual drugs. Fungi are organisms with enormous potential for biodegradation of a variety of toxic chemical pollutants. The aim of this work was to estimate tolerance of fi ve fungal strains to selected anticancer drugs, which will be useful to determine the potential for their possible use in cytostatics removal and may be signifi cant in the context of wastewater treatment application. Test was conducted on Fomes fomentarius (CB13), Hypholoma fasciculare (CB15), Phyllotopsis nidulans (CB14), Pleurotus ostreatus (BWPH) and Trametes versicolor (CB8) and the chosen drugs were bleomycin and vincristine. Their ability to grow in the presence of selected cytostatics was
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白腐真菌对细胞抑制药物博来霉素和长春新碱的耐受性
细胞抑制药物已成为最大的环境危害之一。它们对动植物(包括人类)具有毒性、致癌性、诱变性和致畸性。它们在常规废水处理厂的去除率很差,它们的混合物可能比单个药物具有更高的生态毒性。真菌是一种对各种有毒化学污染物具有巨大生物降解潜力的生物。这项工作的目的是估计五种真菌菌株对选定的抗癌药物的耐受性,这将有助于确定它们在细胞抑制剂去除方面的潜在应用,并可能在废水处理应用的背景下具有重要意义。分别对fomentarius (CB13)、fasiculare (CB15)、Phyllotopsis ndulans (CB14)、Pleurotus ostreatus (BWPH)和Trametes versicolor (CB8)进行试验,选用药物为博来霉素和长春新碱。它们在选定的细胞抑制剂存在下的生长能力是
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来源期刊
Archives of Environmental Protection
Archives of Environmental Protection ENVIRONMENTAL SCIENCES-
CiteScore
2.70
自引率
26.70%
发文量
0
期刊介绍: Archives of Environmental Protection is the oldest Polish scientific journal of international scope that publishes articles on engineering and environmental protection. The quarterly has been published by the Institute of Environmental Engineering, Polish Academy of Sciences since 1975. The journal has served as a forum for the exchange of views and ideas among scientists. It has become part of scientific life in Poland and abroad. The quarterly publishes the results of research and scientific inquiries by best specialists hereby becoming an important pillar of science. The journal facilitates better understanding of environmental risks to humans and ecosystems and it also shows the methods for their analysis as well as trends in the search of effective solutions to minimize these risks.
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