Effect Of Fenugreek And Curry Leaves Powder On Dyslipidemia- A Randomized Controlled Pilot Study

Syeda Farha S, Shivani Agarwal, Vanitha Reddy P
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Abstract

Background: Dyslipidemias, a disorder of lipid metabolism, is widely established as an independent major and modifiable risk factor of cardiovascular disease (CVD). The conditions are common worldwide and a leading cause of death in India, and has even riven the age bar swaying in young people too. The significant effect of an increase in dyslipidemias depends on diabetes and hypertension. Nutraceuticals, derived from food sources serve as an alternative therapy for the management of dyslipidemia. India is home to multitudinous medicinal plants, of which many remain underutilized. Murraya Koenigii (curry leaf) and Trigonella foenum-graecum (fenugreek leaves) are well-proven as good sources of nutraceutical and functional foods. Objectives: To study the effect of fenugreek and curry leaves powder on dyslipidemia and also the dietary habits of dyslipidemic subjects. Materials and methods: 31 subjects aged between 40 and 70 years were recruited based on inclusion and exclusion criteria, and grouped into group 1(hypertensive with dyslipidemia), group 2 (diabetic with dyslipidemia), and group 3 (only dyslipidemia) supplemented with the mixture of fenugreek and curry leaf powder for 3 months. Results: Reduction in total cholesterol and triglyceride levels were observed in group 2 (DM þ DLP) and group 1 (HTN þ DLP) i.e 221.2 ± 29 and 193 ± 72.4 respectively. The HDL levels increased in all three groups. Reduced VLDL and FBS levels were observed in all three groups. Conclusion: Our findings showed that fenugreek and curry leaf powder supplementation, as a phenolic-rich herb can be effective in the reduction of some lipid profiles in dyslipidemic patients suggesting their potential neutraceutical role in treating CVD.
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胡芦巴和咖喱叶粉对血脂异常的影响——一项随机对照的初步研究
背景:血脂异常是一种脂质代谢紊乱,被广泛认为是心血管疾病(CVD)的一个独立的、主要的、可改变的危险因素。这种情况在世界范围内很常见,也是印度的主要死亡原因,甚至还使年轻人的年龄界限摇摆不定。血脂异常增加的显著影响取决于糖尿病和高血压。从食物中提取的营养保健品是治疗血脂异常的一种替代疗法。印度是众多药用植物的家园,其中许多仍未得到充分利用。Murraya Koenigii(咖喱叶)和Trigonella foenum-graecum(葫芦巴叶)已被证明是营养保健和功能性食品的良好来源。目的:研究胡芦巴咖喱叶粉对血脂异常的影响及血脂异常人群的饮食习惯。材料与方法:根据纳入和排除标准,招募年龄在40 ~ 70岁之间的31名受试者,分为1组(高血压合并血脂异常)、2组(糖尿病合并血脂异常)和3组(仅血脂异常),并辅以胡芦巴咖喱叶粉合剂,疗程3个月。结果:2组(DM + DLP)和1组(HTN + DLP)总胆固醇和甘油三酯水平分别降低221.2±29和193±72.4。三组的高密度脂蛋白水平均有所上升。三组均观察到VLDL和FBS水平降低。结论:我们的研究结果表明,胡芦巴和咖喱叶粉作为一种富含酚类物质的草药,可以有效地降低血脂异常患者的一些脂质谱,这表明它们在治疗心血管疾病方面具有潜在的中性作用。
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