{"title":"Tight Junctional Damage in Experimental Mumps‐Associated Hydrocephalus","authors":"M. Uno, T. Takano, T. Yamano, M. Shimada","doi":"10.1111/j.1741-4520.1997.tb00974.x","DOIUrl":null,"url":null,"abstract":"Tight junctions in the central nervous system (CNS) are a major component of brain barriers including the blood‐brain barrier (BBB) and blood‐CSF barrier, which regulate solute entry and protect against invasion by microorganisms. In this study, we examined the breach of tight junctions in mumps virus‐induced hydrocephalic brain in hamsters using antibodies to Laminin B1 chain and zonula occludentes (ZO‐1) immuno‐histochemistry, and evaluated the role of tight junctions in the pathogenesis of hydrocephalus after mumps virus infection.","PeriodicalId":93953,"journal":{"name":"Congenital anomalies","volume":"136 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"1997-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Congenital anomalies","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/j.1741-4520.1997.tb00974.x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
Tight junctions in the central nervous system (CNS) are a major component of brain barriers including the blood‐brain barrier (BBB) and blood‐CSF barrier, which regulate solute entry and protect against invasion by microorganisms. In this study, we examined the breach of tight junctions in mumps virus‐induced hydrocephalic brain in hamsters using antibodies to Laminin B1 chain and zonula occludentes (ZO‐1) immuno‐histochemistry, and evaluated the role of tight junctions in the pathogenesis of hydrocephalus after mumps virus infection.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
