Using expression data to help pathway curation

Abstract

Pathway models for organisms beyond the most popular model organisms are often notoriously incomplete, even for commercially important species such as gallus gallus. This can make experimental expression data hard to interpret. The paper describes ESCAPE [Experimental System for Curation Assistance of Pathways via Espression data], under development to use available expression data, along with existing orthology mappings and curated machine-interpretable pathways, to assist in rapidly curating new species-specific pathways. Some of these techniques can also be extended to help in the analysis of the expression data in a curated pathway context as well.