Drug Combination Strategy: Pharmacokinetics and Drug-Drug Interaction Considerations in Diseased Patients

N. Srinivas
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Abstract

The availability of fixed dose combinations (FDC) continues to be on the rise since they provide convenience and compliance for the disease management [1,2]. Given the involvement of polypharmacy in the current disease management for certain chronic ailments, the development of newer FDC combinations to benefit patients in a disease area is amply justified [3,4]. A recent publication on this important topic lays out a strategy and framework for an unequivocal and unbiased evaluation of FDC product from a pharmacokinetic perspective [5]. Some key topics of discussion in this paper includes the attributes that contribute for the dose selection of the individual FDC drug components and the key features to determine the extent (or lack) of a pharmacokinetic drug-drug interaction between the two drugs in the FDC [5]. The intent of this editorial is to provide some perspectives on the altered changes in physiology in disease patients that may likely have an influence on the pharmacokinetic disposition of drugs that are used in the combination strategy.
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药物联合策略:患病患者的药代动力学和药物-药物相互作用考虑
固定剂量组合(FDC)的可用性持续上升,因为它们为疾病管理提供了便利性和合规性[1,2]。考虑到多种药物在当前某些慢性疾病的疾病管理中的作用,开发新的FDC组合以使疾病领域的患者受益是充分合理的[3,4]。最近一份关于这一重要主题的出版物从药代动力学的角度提出了对FDC产品进行明确和公正评价的策略和框架[10]。本文讨论的一些关键主题包括有助于FDC单个药物成分剂量选择的属性,以及确定FDC bb0中两种药物之间药代动力学药物相互作用程度(或缺乏)的关键特征。这篇社论的目的是提供一些关于疾病患者生理变化的观点,这些变化可能对联合用药策略中使用的药物的药代动力学处置有影响。
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