The Pharmacogenetics of Treatment with Quetiapine

María Ortega-Ruiz, Paula Soria-Chacartegui, Gonzalo Villapalos-García, F. Abad‐Santos, P. Zubiaur
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引用次数: 1

Abstract

Quetiapine is a second-generation antipsychotic used for the treatment of schizophrenia, depression and bipolar disorder. The aim of this traditional review was to summarize the available pharmacogenetic information on this drug and to conclude about its clinical relevance. For this purpose, bibliographic research was performed in the Pharmacogenomics Knowledge Base (PharmGKB) database. A total of 23 articles were initially retrieved, of which 15 were finally included. A total of 19 associations were observed between 15 genes, such as CYP3A4, CYP3A5, COMT or MC4R, and 29 clinical events. No associations were consistently replicated between pharmacogenetic biomarkers and clinical events, except for that between the CYP3A4 phenotype and quetiapine exposure, which was the only one considered clinically relevant. Consistently, the DPWG published a clinical guideline on this association, where dose adjustments for CYP3A4 poor metabolizers (PMs) are indicated to prevent the occurrence of adverse drug reactions (ADRs).
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喹硫平治疗的药物遗传学
喹硫平是第二代抗精神病药物,用于治疗精神分裂症、抑郁症和双相情感障碍。这篇传统综述的目的是总结有关该药物的现有药理学信息,并总结其临床相关性。为此,在Pharmacogenomics Knowledge Base (PharmGKB)数据库中进行了文献研究。最初共检索到23篇文章,其中15篇最终被纳入。共观察到CYP3A4、CYP3A5、COMT或MC4R等15个基因与29个临床事件之间的19种关联。药物遗传生物标志物与临床事件之间没有一致的关联,除了CYP3A4表型与喹硫平暴露之间的关联,这是唯一被认为与临床相关的关联。与此一致,DPWG发布了一份关于这种关联的临床指南,其中指出CYP3A4代谢不良药物(PMs)的剂量调整是为了防止药物不良反应(adr)的发生。
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