{"title":"Effect of Withania somnifera on Lysosomal Acid Hydrolases in Adjuvant‐induced Arthritis in Rats","authors":"M. Rasool, L. M. Latha, P. Varalakshmi","doi":"10.1211/146080800128735863","DOIUrl":null,"url":null,"abstract":"The effect of Withania somnifera Linn. Dunal (Solanaceae) on adjuvant arthritic rats was studied and compared with that of indomethacin. \n \n \n \nThese results indicate that Withania somnifera has promising anti-arthritic activity as a result of its stabilizing action on lysosomal enzyme activity. \n \n \n \nThe anti-inflammatory activity of Withania somnifera was assessed by measuring paw swelling and lysosomal enzyme activity in control and experimental rats. Increased paw diameter and lysosomal enzyme activity in the arthritic animals were significantly suppressed to near normal levels in rats treated with 1000 mg kg−1Withania somnifera root powder and 3 mg kg−1 indomethacin.","PeriodicalId":19946,"journal":{"name":"Pharmacy and Pharmacology Communications","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2000-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"31","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacy and Pharmacology Communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1211/146080800128735863","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 31
Abstract
The effect of Withania somnifera Linn. Dunal (Solanaceae) on adjuvant arthritic rats was studied and compared with that of indomethacin.
These results indicate that Withania somnifera has promising anti-arthritic activity as a result of its stabilizing action on lysosomal enzyme activity.
The anti-inflammatory activity of Withania somnifera was assessed by measuring paw swelling and lysosomal enzyme activity in control and experimental rats. Increased paw diameter and lysosomal enzyme activity in the arthritic animals were significantly suppressed to near normal levels in rats treated with 1000 mg kg−1Withania somnifera root powder and 3 mg kg−1 indomethacin.
苦参的药效研究。研究了茄科杜纳尔对佐剂性关节炎大鼠的作用，并与吲哚美辛进行了比较。这些结果表明，苦参对溶酶体酶活性具有稳定作用，具有良好的抗关节炎活性。通过测定对照组大鼠和实验大鼠的足跖肿胀和溶酶体酶活性来评价苦参的抗炎活性。用1000 mg kg - 1苦参根粉和3 mg kg - 1吲哚美辛处理后，关节炎动物的足径增加和溶酶体酶活性明显被抑制到接近正常水平。
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