The potential role of DJ-1 in fibrogenesis: A double-edged sword?

Bioscience hypotheses Pub Date : 2009-01-01 DOI:10.1016/j.bihy.2009.04.002

Shunfang Liu , Jilin Yi , Gang Xu , Honglan Wei

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Abstract

Fibrogenesis is a frequent pathogenesis in the processes of many diseases from the initial-stage to the end-stage. Unfortunately, mechanisms of fibrogenesis are complex and not fully understood by now. Recently, researches have proved that oxidative stress participates in the process of fibrosis. Some studies suggest that PTEN, a tumor suppressor, is down-regulated in fibrosis, and it will be a new agent for fighting against fibrogenesis. DJ-1, an oncogene product, has been identified as a protein with various functions in cellular transformation, oxidative stress response and transcriptional regulation, and it is considered as a negative regulator of PTEN in tumor. DJ-1 is also observed overexpression in hepatic fibrosis, but the specific effects of it are obscure. We hypothesize that DJ-1 is a double-edged sword in fibrogenesis: DJ-1 may hamper oxidative damage; overexpression of DJ-1 possibly promote fibrogenesis through depressing the expression of PTEN and activating PI3K/Akt pathway subsequently.

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DJ-1在纤维形成中的潜在作用:一把双刃剑?

纤维发生是许多疾病从早期到终末期过程中常见的发病机制。不幸的是，纤维形成的机制是复杂的，目前还没有完全了解。近年来，研究证实氧化应激参与了纤维化的过程。一些研究表明PTEN是一种肿瘤抑制因子，在纤维化过程中被下调，它将成为一种新的抗纤维化药物。DJ-1是一种癌基因产物，在细胞转化、氧化应激反应和转录调控中具有多种功能，被认为是肿瘤中PTEN的负调控蛋白。DJ-1在肝纤维化中也有过表达，但其具体作用尚不清楚。我们假设DJ-1在纤维形成过程中是一把双刃剑:DJ-1可能阻碍氧化损伤;DJ-1过表达可能通过抑制PTEN的表达进而激活PI3K/Akt通路促进纤维形成。

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Bioscience hypotheses

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