Multiple Sclerosis and Gene Polymorphisms: are we Groping in the Dark?

E. Haq
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引用次数: 2

Abstract

Copyright: © 2015 Haq E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Till date, the etiology of multiple sclerosis (MS) remains convoluted and many recent studies have added some startling findings to the existing literature on MS. There have been some noticeable developments in dissecting genetics of MS, but the results remain controversial due to divergence in geographic prevalence of MS across different populations. By and large this may be attributed to the enigmatic genetic and environmental background in its etiopathogenesis. By unlocking the missing link between these two components, some advancement can be achieved in devising better treatment options for MS management. This commentary highlights the outcome of our recent study aimed at exploring the association between MS susceptibility and EIF2B5 Ile587Val polymorphism in a subset of Indian population [1].
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多发性硬化症和基因多态性:我们是在黑暗中摸索吗?
版权所有:©2015 Haq E, et al。这是一篇根据知识共享署名许可协议发布的开放获取文章,该协议允许在任何媒体上不受限制地使用、分发和复制,前提是要注明原作者和来源。迄今为止,多发性硬化症(MS)的病因仍然很复杂,最近的许多研究为MS的现有文献增加了一些惊人的发现。MS的解剖遗传学有了一些显著的进展,但由于MS在不同人群中的地理患病率存在差异,结果仍然存在争议。总的来说,这可能归因于其发病机制中神秘的遗传和环境背景。通过解开这两个组成部分之间缺失的联系,可以在为MS管理设计更好的治疗方案方面取得一些进展。这篇评论强调了我们最近研究的结果,该研究旨在探索印度人群中一个亚群中MS易感性与EIF2B5 Ile587Val多态性之间的关系[1]。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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