DETERMINING THE THERMODYNAMIC DISSOCIATION CONSTANTS OF 5-BROMO-6,7-DIHYDROXY-N-METHYL-3-SULFOQUINOLINE IN AQUEOUS SOLUTION AT 25 OC BY POTENTIOMETRIC METHOD
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Abstract
In this report, the thermodynamic dissociation constants of 5-bromo-6,7- dihydroxy-N-methyl-3-sulfoquinoline (signed H2BDMS) acid were firstly determined in the aqueous solution using potentiometric titration at (25.0 ± 0.1) oC in the ionic medium of 0.10 M KCl solution. This new acid is a compound containing the quinoline ring that may be applied in many branches of chemistry, biology, and medicine. The pKa values of H2BDMS acid which were determined by the potentiometric method are pKa1 = 2.79 ± 0.02 and pKa2 = 7.80 ± 0.06. To increase the precision and accuracy of the results, the pKa values were calculated at various concentration levels. The structure of the new acid and data of potentiometric titration were analyzed in detail before calculating and assigning the pKa values to suitable functional groups. These results will be applied to our further studies of this compound.
本文首次在离子介质0.10 M KCl溶液中，采用(25.0±0.1)℃电位滴定法测定了5-溴-6,7-二羟基- n -甲基-3-磺基喹啉(H2BDMS)酸的热力学解离常数。这种新型酸是一种含有喹啉环的化合物，可用于化学、生物学和医学的许多分支。电位法测定H2BDMS酸的pKa值为pKa1 = 2.79±0.02,pKa2 = 7.80±0.06。为了提高结果的精密度和准确度，计算了不同浓度下的pKa值。对新酸的结构和电位滴定数据进行了详细的分析，计算并确定了合适的官能团的pKa值。这些结果将应用于我们对该化合物的进一步研究。
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