T. Imajima, Mamoru Ito, Y. Shinohara, K. Tsuchihashi, H. Ariyama, H. Kusaba, Hidetaka Yamamoto, Y. Oda, K. Akashi, E. Baba
{"title":"Favorable response to combined androgen blockade for metastatic cutaneous\n apocrine carcinoma: a case report","authors":"T. Imajima, Mamoru Ito, Y. Shinohara, K. Tsuchihashi, H. Ariyama, H. Kusaba, Hidetaka Yamamoto, Y. Oda, K. Akashi, E. Baba","doi":"10.1097/IJ9.0000000000000105","DOIUrl":null,"url":null,"abstract":"Introduction: Most cases of cutaneous apocrine carcinoma (CAC) express androgen receptor. Androgen signal is thought to have a relationship on the survival and cell growth of the tumor. Presentation of Case: A 53-year-old man with a red superficial nodule on the left axilla and a back pain was diagnosed with CAC in the left axilla with multiple bone and bone marrow metastases. After cytotoxic chemotherapy for around 4 years, severe anemia, thrombocytopenia, and disseminated intravascular coagulation progressed. We started combined androgen blockade by bicaltamide and degarelix, and the therapy had successfully maintained stable disease for more than 6 months. Discussion: Most cases of CAC express androgen receptor. Androgen signal could have a relationship on the survival and cell growth of the tumor. Conclusion: Antiandrogen therapy for androgen-receptor positive CAC is a promising therapeutic option.","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":null,"pages":null},"PeriodicalIF":0.3000,"publicationDate":"2021-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Surgery-Oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/IJ9.0000000000000105","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Most cases of cutaneous apocrine carcinoma (CAC) express androgen receptor. Androgen signal is thought to have a relationship on the survival and cell growth of the tumor. Presentation of Case: A 53-year-old man with a red superficial nodule on the left axilla and a back pain was diagnosed with CAC in the left axilla with multiple bone and bone marrow metastases. After cytotoxic chemotherapy for around 4 years, severe anemia, thrombocytopenia, and disseminated intravascular coagulation progressed. We started combined androgen blockade by bicaltamide and degarelix, and the therapy had successfully maintained stable disease for more than 6 months. Discussion: Most cases of CAC express androgen receptor. Androgen signal could have a relationship on the survival and cell growth of the tumor. Conclusion: Antiandrogen therapy for androgen-receptor positive CAC is a promising therapeutic option.
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