Evaluation of patient with Holt-Oram syndrome in terms of oral and maxillofacial findings

Abstract

The Holt-Oram syndrome (HOS) is a genetic disorder with autosomal dominant inheritance associated with anomalies in upper extremities and heart and affects one out of every 100,000 live births. Maxillofacial development is also affected by these skeletal abnormalities. Although there are many studies about the HOS in the literature, the data about the development of oral and maxillofacial development are very few. In this study, evaluation of a child with the HOS is made in terms of dental and gingival health, oral and maxillofacial formation, and cephalometric analysis measurements are made for the 1 st time in the literature and identified findings are discussed in company with the literature.