Pure White Cell Aplasia and Immune Thrombocytopenia after Thymoma Resection: A Case Report and Review of the Literature.

IF 2.5 3区 物理与天体物理 Q2 OPTICS Optics Communications Pub Date : 2022-03-22 eCollection Date: 2022-01-01 DOI:10.1155/2022/8271069
Michael Youssef, Tyler W Stratton, Reid C Gallant, Christine Young, Daniel Y Li, Siavash Piran
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Abstract

We report a case of pure white cell aplasia (PWCA) postthymoma resection in a 74-year-old male presenting with a 2-week history of fevers, night sweats, and severe febrile neutropenia. His pure white cell aplasia was treated with intravenous immunoglobulin (IVIg), granulocyte colony-stimulating factor (G-CSF), prednisone, and cyclosporine with a mixed response. He also developed immune thrombocytopenia, which responded well to a short course of eltrombopag. With continued cyclosporine treatment, his platelet counts were stable after stopping eltrombopag. The patient's cyclosporine treatment was complicated by renal failure, resulting in cessation of cyclosporine. His PWCA and immune thrombocytopenia significantly worsened after stopping cyclosporine, and unfortunately, he died from multiorgan failure and sepsis.

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胸腺瘤切除术后的纯白细胞增生症和免疫性血小板减少症:病例报告和文献综述。
我们报告了一例胸腺瘤切除术后纯白细胞增生症(PWCA)病例,患者是一名74岁的男性,两周前出现发热、盗汗和严重的发热性中性粒细胞减少症。他的纯白细胞再生障碍曾接受静脉注射免疫球蛋白(IVIg)、粒细胞集落刺激因子(G-CSF)、泼尼松和环孢素治疗,但疗效不一。他还出现了免疫性血小板减少症,短期服用艾曲波帕(eltrombopag)后反应良好。在继续使用环孢素治疗的情况下,他的血小板计数在停用艾曲波帕后保持稳定。该患者的环孢素治疗因肾功能衰竭而变得复杂,因此停止了环孢素治疗。停用环孢素后,他的PWCA和免疫性血小板减少症明显恶化,不幸死于多器官功能衰竭和败血症。
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来源期刊
Optics Communications
Optics Communications 物理-光学
CiteScore
5.10
自引率
8.30%
发文量
681
审稿时长
38 days
期刊介绍: Optics Communications invites original and timely contributions containing new results in various fields of optics and photonics. The journal considers theoretical and experimental research in areas ranging from the fundamental properties of light to technological applications. Topics covered include classical and quantum optics, optical physics and light-matter interactions, lasers, imaging, guided-wave optics and optical information processing. Manuscripts should offer clear evidence of novelty and significance. Papers concentrating on mathematical and computational issues, with limited connection to optics, are not suitable for publication in the Journal. Similarly, small technical advances, or papers concerned only with engineering applications or issues of materials science fall outside the journal scope.
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