{"title":"Detection of Single Biological Cells using a DVD Pickup Head","authors":"S. Kostner, M. Vellekoop","doi":"10.1109/SENSOR.2007.4300585","DOIUrl":null,"url":null,"abstract":"In this paper we present an optical detection system for single biological cells that utilizes a standard DVD pickup head. In a feasibility study we have shown the detection for different plain and silver coated polystyrene particles and cells (yeast) suspended on a platinum mirror. For these experiments the integrated magnetic actor of the pickup was used to simulate the particle movement and we found a remarkable sensitivity. Then a flow cell with integrated mirror has been designed to be able to measure particles in a cytometric setup. First measurement results are given that show the high sensitivity and a good repeatability for polystyrene beads.","PeriodicalId":23295,"journal":{"name":"TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference","volume":"224 1","pages":"2123-2126"},"PeriodicalIF":0.0000,"publicationDate":"2007-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/SENSOR.2007.4300585","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 7
Abstract
In this paper we present an optical detection system for single biological cells that utilizes a standard DVD pickup head. In a feasibility study we have shown the detection for different plain and silver coated polystyrene particles and cells (yeast) suspended on a platinum mirror. For these experiments the integrated magnetic actor of the pickup was used to simulate the particle movement and we found a remarkable sensitivity. Then a flow cell with integrated mirror has been designed to be able to measure particles in a cytometric setup. First measurement results are given that show the high sensitivity and a good repeatability for polystyrene beads.
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