Surgical methods of retinal pigment epithelium transplantation in rabbits in experiment

IF 0.9 Q4 OPHTHALMOLOGY Current Ophthalmology Reports Pub Date : 2023-04-09 DOI:10.17816/ov237101

N. V. Neroeva, M. Lagarkova, P. A. Ilyukhin, N. S. Izmailova, O. A. Utkina, P. Laktionov, V. Chernonosova, Anatoly E. Kharitonov

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Abstract

The article is devoted to the study of surgical methods of retinal pigment epithelium transplantation in experiment on rabbits. The history of retinal pigment epithelium transplantation is briefly characterized in the study. Characteristics of the methods used are presented, their limitations, possibilities, and requirements for implementation in practice are highlighted. The results of transplantation of suspension of retinal pigment epithelium cells differentiated from human induced pluripotent stem cells (IPSC-RPE) without and with the use of platelet-rich blood plasma (PRP) are also considered. According to the results of the analysis we have developed modified methods of IPSC-RPE cells transplantation in the experiment on rabbits, which allow to reduce the number of postoperative complications, which provides the best therapeutic effect. Prospects for further studies are associated with a comparative analysis of the proposed techniques in terms of cell survival at different terms, anatomical integration and functional efficiency in the dynamics.

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实验兔视网膜色素上皮移植的手术方法

本文研究了兔视网膜色素上皮移植的手术方法。本研究简要介绍了视网膜色素上皮移植的历史。介绍了所使用的方法的特点，强调了它们的局限性、可能性和在实践中实施的要求。我们还考虑了在不使用富血小板血浆(PRP)和使用富血小板血浆(PRP)的情况下，将人诱导多能干细胞(IPSC-RPE)分化的视网膜色素上皮细胞悬浮液移植的结果。根据分析结果，我们在家兔实验中开发了改良的IPSC-RPE细胞移植方法，减少了术后并发症的发生，提供了最佳的治疗效果。进一步研究的前景与所提出的技术在不同条件下的细胞存活、解剖学整合和动力学中的功能效率方面的比较分析有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Ophthalmology Reports Medicine-Ophthalmology

CiteScore

2.00

自引率

0.00%

发文量

期刊介绍： This journal aims to offer expert review articles on the most significant recent developments in the field of ophthalmology. By providing clear, insightful, balanced contributions, the journal intends to serve those who diagnose, treat, manage, and prevent ocular conditions and diseases. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An Editorial Board of more than 20 internationally diverse members reviews the annual table of contents, ensures that topics include emerging research, and suggests topics of special importance to their country/region. Topics covered may include age-related macular degeneration; diabetic retinopathy; dry eye syndrome; glaucoma; pediatric ophthalmology; ocular infections; refractive surgery; and stem cell therapy.