{"title":"The interaction of formaldehyde, isothiazolone and copper","authors":"H.W. Rossmoore","doi":"10.1016/0265-3036(90)90062-C","DOIUrl":null,"url":null,"abstract":"<div><p>Evidence has been presented for the synergism between copper (Cu) and formaldehyde (FA) and isothiazolone (IT) and also for the equivalence of many FA adducts with FA. A distinction as well as a dual site for Cu-IT interaction has been made with both protection from environmental nucleophiles as well as enhancement of antimicrobial activity. Since the major FA dehydrogenase associated with FA resistance is glutathione dependent, the prospect of Cu-glutathione interaction is a probable cause of Cu-FA synergism.</p><p>Although there is no clear explanation for the IT-FA synergism, the combination offers many avenues for future exploration.</p></div>","PeriodicalId":13629,"journal":{"name":"International Biodeterioration","volume":"26 2","pages":"Pages 225-235"},"PeriodicalIF":0.0000,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0265-3036(90)90062-C","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Biodeterioration","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/026530369090062C","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 7
Abstract
Evidence has been presented for the synergism between copper (Cu) and formaldehyde (FA) and isothiazolone (IT) and also for the equivalence of many FA adducts with FA. A distinction as well as a dual site for Cu-IT interaction has been made with both protection from environmental nucleophiles as well as enhancement of antimicrobial activity. Since the major FA dehydrogenase associated with FA resistance is glutathione dependent, the prospect of Cu-glutathione interaction is a probable cause of Cu-FA synergism.
Although there is no clear explanation for the IT-FA synergism, the combination offers many avenues for future exploration.
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