Optical coefficient measurements using bulk living tissue with optical fiber puncture

Q4 Engineering Transactions of Japanese Society for Medical and Biological Engineering Pub Date : 2017-05-03 DOI:10.11239/JSMBE.55ANNUAL.597

Haruna Nakazawa, Marika Doi, E. Ogawa, T. Arai

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Abstract

(one line blank) Abstract: Slicing sample preparation in tissue optical characteristic measurement may makes huge error over individual optical differences. We proposed the combination of light intensity measurement through an optical fiber puncturing into a bulk tissue varying detection numerical aperture and ray tracing calculation to avoid slicing degradation of living tissue. To reveal the characteristics of this measurement, optical coefficients of pig myocardium obtained by the IAD method with slicing living tissue sample preparation and proposed measurement method were compared. In the proposed method, a silica fiber installed in an18G needle was punctured up to the bottom of the myocardial bulk tissue to measure light intensity in the bulk tissue changing depth and numerical aperture. The author found that measured apparent attenuation coefficients tended to strongly depend on numerical aperture. The ray trace calculation explained the same numerical aperture tendency in above mentioned experimental result. Optical characteristics of sliced myocardial samples revealed temporal change due to dehydration.

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光学系数测量使用散装活组织与光纤穿刺

摘要:切片样品制备在组织光学特性测量中可能会由于个体光学差异而产生巨大的误差。为了避免活体组织的切片降解，我们提出了通过光纤刺入散装组织进行光强测量，改变检测数值孔径和射线追踪计算相结合的方法。为了揭示该测量方法的特点，比较了采用切片活组织样品制备的IAD法获得的猪心肌光学系数和所提出的测量方法。该方法采用18g针头将二氧化硅纤维刺穿至心肌体组织底部，测量光强在体组织中的变化深度和数值孔径。结果表明，实测的视衰减系数与数值孔径有很大的关系。射线迹计算解释了上述实验结果中相同的数值孔径趋势。切片心肌样品的光学特征显示脱水引起的时间变化。

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来源期刊

Transactions of Japanese Society for Medical and Biological Engineering Engineering-Biomedical Engineering

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0.10

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0.00%

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