Giant Parathyroid Adenomas: Differential Aspects Compared to Atypical Parathyroid Adenomas

Abstract

Primary hyperparathyroidism is a common diagnosis, often caused by a parathyroid adenoma, which can be resolved with surgical excision. However, pre-operative diagnosis of the causative adenoma may be challenging given the overlapping presentations and laboratory findings in typical, giant, and atypical parathyroid adenomas. In this case series, we describe one of the largest giant parathyroid adenomas excised in the United States and compare its presentation to that of an atypical parathyroid adenoma. Using this comparison, we aim elucidate the diagnostic value of various presentation characteristics, such as adenoma size, mass effect, symptom burden, and biochemical derangements.