Intra-Biliary Colorectal Metastasis in Lynch Syndrome: Fifteen Years After the Index Cancer

Anju Mullath, A. Koshy, Roy j. Mukkada, A. Chettupuzha, S. Paul, P. Mathew, P. Mahadevan, Murali Krishna
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Abstract

Tropical Gastroenterology 96 The duration of antifungal treatment is guided by the resolution of clinical and radiological features which may take 6 to 8 weeks. The recommended therapeutic drug level of posaconazole is a trough concentration of 1 μg/mL or higher4. Delayed presentation with inability to remove the infected intestinal segment and use of parenteral antifungal therapy alone in an immunocompromised patient might have led to fatality in our case. Therefore, a high degree of clinical suspicion, early diagnosis and prompt surgical debridement with anti -fungal therapy might improve survival.
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Lynch综合征的胆道内结直肠转移:指数癌后15年
抗真菌治疗的持续时间取决于临床和放射学特征的解决,可能需要6至8周。泊沙康唑的推荐治疗药物浓度为谷浓度1 μg/mL或更高4。在我们的病例中,由于无法切除受感染的肠段而延迟出现,并且在免疫功能低下的患者中单独使用肠外抗真菌治疗可能导致死亡。因此,高度的临床怀疑,早期诊断和及时手术清创配合抗真菌治疗可能提高生存率。
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