{"title":"Arabinoxylan-Based Mucoadhesive Oral Films of Tizanidine HCL Designed and Optimized Using Central Composite Rotatable Design","authors":"M. Zaman, Muhammad Hanif, M. A. Khan","doi":"10.1080/03602559.2017.1324575","DOIUrl":null,"url":null,"abstract":"ABSTRACT In the current study, a natural pharmaceutical excipient, arabinoxylan, was extracted from ispaghula husk and used to develop controlled release of mucoadhesive oral films of tizanidine hydrochloride. Film formulations were designed and optimized by central composite rotatable design, selecting arabinoxylan (X1) and glycerol (X2) as variables. Prepared films were evaluated for chemical compatibility of the ingredients, surface morphology, mechanical strength, in vitro drug release, ex vivo drug permeation and ex vivo mucoadhesion strength. Results revealed that selected ingredients were compatible and quite capable of producing films with desired characteristics. GRAPHICAL ABSTRACT","PeriodicalId":20629,"journal":{"name":"Polymer-Plastics Technology and Engineering","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"10","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Polymer-Plastics Technology and Engineering","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/03602559.2017.1324575","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Materials Science","Score":null,"Total":0}
引用次数: 10
Abstract
ABSTRACT In the current study, a natural pharmaceutical excipient, arabinoxylan, was extracted from ispaghula husk and used to develop controlled release of mucoadhesive oral films of tizanidine hydrochloride. Film formulations were designed and optimized by central composite rotatable design, selecting arabinoxylan (X1) and glycerol (X2) as variables. Prepared films were evaluated for chemical compatibility of the ingredients, surface morphology, mechanical strength, in vitro drug release, ex vivo drug permeation and ex vivo mucoadhesion strength. Results revealed that selected ingredients were compatible and quite capable of producing films with desired characteristics. GRAPHICAL ABSTRACT
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