{"title":"Anti-inflammatory and Antinociceptive Effects of the Alcoholic Extract of Indian Polygala arvensis in Experimental Animals","authors":"G. Sammaiah, K. Thirupathi, R. Srivastava","doi":"10.4314/ECAJPS.V10I2.9760","DOIUrl":null,"url":null,"abstract":"The alcoholic extract of Polygala arvensis (family Polygalaceae) was screened for antinociceptive and anti-inflammatory activities in experimental animals. The extract was administered for three consecutive days. Following an oral dose of 25 - 100 mg/kg, the extract exhibited graded dose response equivalent to 16.24% - 55.43% protection in the tail flick latent test in rats. Oral doses of 50 and 100 mg/kg of the extract administered to mice effectively increased reaction time in the hot plate method by 69.55% (p Keywords : Polygala arvensis , alcoholic extract, antinociceptive, anti-inflammatory East and Central African Journal of Pharmaceutical Sciences Vol. 10 (2) 2007: pp. 39-44","PeriodicalId":22387,"journal":{"name":"The East and Central African Journal of Pharmaceutical Sciences","volume":"11 1","pages":"39-44"},"PeriodicalIF":0.0000,"publicationDate":"2008-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The East and Central African Journal of Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4314/ECAJPS.V10I2.9760","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
The alcoholic extract of Polygala arvensis (family Polygalaceae) was screened for antinociceptive and anti-inflammatory activities in experimental animals. The extract was administered for three consecutive days. Following an oral dose of 25 - 100 mg/kg, the extract exhibited graded dose response equivalent to 16.24% - 55.43% protection in the tail flick latent test in rats. Oral doses of 50 and 100 mg/kg of the extract administered to mice effectively increased reaction time in the hot plate method by 69.55% (p Keywords : Polygala arvensis , alcoholic extract, antinociceptive, anti-inflammatory East and Central African Journal of Pharmaceutical Sciences Vol. 10 (2) 2007: pp. 39-44
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