Study on the reactions between dichlorido[2,2′:6′,2″-terpyridine] zinc(II) and biologically relevant nucleophiles in aqueous solution

IF 2.1 4区 化学 Q3 CHEMISTRY, PHYSICAL Progress in Reaction Kinetics and Mechanism Pub Date : 2019-04-22 DOI:10.1177/1468678319825724
Enisa Selimović, T. Soldatović
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引用次数: 1

Abstract

Substitution reactions of square-pyramidal [ZnCl2(terpy)] complex (terpy = 2,2′:6′,2″-terpyridine) with biologically relevant nucleophiles such as imidazole, glutathione, 1,2,4-triazole, and pyrazine were investigated at pH 7.0 as a function of nucleophile concentration. The reactions were followed under pseudo first-order conditions by UV-Vis spectrophotometry. The substitution reactions comprised two steps of consecutive displacement of chlorido ligands. Different reaction pathways for the first reaction step of nucleophilic substitution were defined. The order of reactivity of the investigated nucleophiles for the first reaction was imidazole > glutathione > pyrazine > 1,2,4-triazole, while for the second reaction step it was pyrazine > 1,2,4-triazole > imidazole > glutathione.
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二氯[2,2 ':6 ',2″-三吡啶]锌(II)与生物相关亲核试剂在水溶液中的反应研究
在pH 7.0条件下,研究了方形锥体[ZnCl2(terpy)]配合物(terpy = 2,2′:6′,2″-terpyridine)与咪唑、谷胱甘肽、1,2,4-三唑和吡嗪等亲核试剂的取代反应。用紫外-可见分光光度法在伪一级条件下对反应进行了跟踪。取代反应包括连续置换氯基配体的两个步骤。定义了亲核取代反应第一步的不同反应途径。亲核试剂第一反应的反应活性顺序为咪唑>谷胱甘肽>吡嗪> 1,2,4-三唑,第二反应顺序为吡嗪> 1,2,4-三唑>咪唑>谷胱甘肽。
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来源期刊
CiteScore
2.10
自引率
0.00%
发文量
5
审稿时长
2.3 months
期刊介绍: The journal covers the fields of kinetics and mechanisms of chemical processes in the gas phase and solution of both simple and complex systems.
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