Considerable Recovery Effect Of EPL And Ashwagandha On The Weight Of Dams And Foetal Weight In Swiss Albino Mice Due To Intoxication Of Mercuric Chloride

IRA-International Journal of Applied Sciences Pub Date : 2016-11-10 DOI:10.21013/JAS.V5.N1.P6

V. Tiwari

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Abstract

Investigations were furnished on the toxic effect of mercuric chloride in foetal weights and weight of dam in mice with remarkable recovery effect of Withania somnifera (Ashwagandha) and Essentiale phospholipids (EPL) were observed. Withania somnifera is popularly known as Indian Ginseng and its withanoid content improves the greater gain in body weight, whereas dilinoleoylphosphatidylcholine content of EPL revealed high affinity with lipid contents of blood which consequently increased adipose tissues of body. The animals were treated with 0.5 ppm aqueous mercuric chloride for a period of 7, 14 and 21 days. For the recovery 175 mg of EPL and 35 mg of ashwagandha were administered to mice (already treated with HgCl 2 ) for a period of 7, 14 and 21 days. Daily treatment of HgCl 2 for 7, 14 and 21 days decreased weight of foetuses and dams. Simultaneous administration of EPL and ashwagandha significantly recovered the weight of foetuses and dams. It appears that the protective effects of EPL and ashwagandha against HgCl 2 induced weight alteration is mediated through antioxidative action of EPL and ashwagandha.

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EPL和Ashwagandha对氯化汞中毒瑞士白化小鼠的体重和胎儿体重有显著的恢复作用

研究了氯化汞对胎儿体重和小鼠体重的毒性作用，并观察了苦参和必需磷脂(EPL)的恢复作用。Withania somnifera俗称印度人参，其类皂苷含量可以促进体重的增加，而EPL的二烯油基磷脂酰胆碱含量与血液脂质含量有很高的亲和力，从而增加了身体的脂肪组织。这些动物被0.5 ppm的氯化汞水处理了7天、14天和21天。为了恢复，将175 mg EPL和35 mg ashwagandha给予小鼠(已经用HgCl 2治疗)，为期7天，14天和21天。每天处理7、14和21 d的hgcl2可降低胎儿和母鼠的体重。同时给药EPL和ashwagandha显著恢复了胎儿和母鼠的体重。EPL和ashashandha对hgcl2诱导的体重改变的保护作用似乎是通过EPL和ashashandha的抗氧化作用介导的。

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IRA-International Journal of Applied Sciences

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