A Study of the Magnetic Nanocomposites with Natural Polymer Coating From the Perspective of the Targeted Drug Delivery

Abstract

Recent research on the resistance of pathogenic bacteria to existing antibiotics has shown the rapid spread of this problem and has raised concerns in scientific circles and international organizations. The development of new antibiotics is still slow in the face of growing needs. In addition, the overuse of antibiotics in developing countries has exacerbated the problem. Therefore, the development of new and multidimensional strategies is necessary to address this global problem. One of the solutions that has been considered by researchers in recent years is the development of targeted drug delivery systems based on magnetic nanoparticles. Unique magnetic properties the physicochemical and physiological properties of magnetic nanoparticles have made them useful as carriers for delivering drugs to the target tissue. In this study, we try to provide a general study to some subjects such as synthesis of magnetic nanoparticles and coating of these nanoparticles with natural polymer to grain (mucilage to grain) as a biocompatible, non-toxic and oral polymeric agent for maximum loading of ciprofloxacin antibiotic on nanostructured nuclei Magnetite and shell to mucilage to grain, to study the effect of different parameters and fabrication conditions of samples on the structural, physicochemical, magnetic, colloidal stability and antibacterial properties of samples, and also to investigate the effect of pH on ciprofloxacin adsorption on magnet nanoparticles by mucilage to the grain and release of the drug from these nanoparticles.