Preparation of Artificial Cerebrospinal Fluid Using Concentrated Electrolyte Injections.

Abstract

Two concentrated electrolyte injections (solution A and B) were used for the rapid and easy preparation of artificial cerebrospinal fluid (ACF). Solution A (10 ml) included Na, K, Mg, Ca, Cl, lactate, and glucose while solution B (20 ml) was composed of KH2 PO4 and NaHCO3. Solution A was first added to 0, 9% NaCl in jection (515 ml) maintained in a soft plastic bag followed by solution B. Notably, the prepared ACF had particulate matter counts far less than the Japanese pharmacopoeia (JP) and United States Pharmacopeia (USP) limits for large volume injections. Application of the present ACF to patients using a ventricular fiberscope caused no significant adverse effects, such as convulsion, headaches or fever.