{"title":"MESOPOROUS SILICA AS A VEHICLE FOR ORGANOTIN(IV) COMPOUNDS","authors":"G. Kaluđerović","doi":"10.46793/iccbi21.060k","DOIUrl":null,"url":null,"abstract":"Free Ph3Sn(CH2)nOH (n = 3, 4, 6, 8 and 11) and immobilized organotin(IV) compounds, SBA- 15~Cl|Ph3Sn(CH2)nOH, were prepared and tested against different tumor cell lines. Both compounds and nanomaterials revealed strong cytotoxic potential. SBA-15~Cl|Ph3Sn(CH2)3OH as well as free compound induce caspase triggered apoptosis in human ovarian A2780 cells. Ph3Sn(CH2)6OH and corresponding nanomaterial induced apoptosis in mouse melanoma B16 cells. Survived clones of B16 cells demonstrated phenotypic changes, they differentiate toward melanocytes.","PeriodicalId":9171,"journal":{"name":"Book of Proceedings: 1st International Conference on Chemo and BioInformatics,","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Book of Proceedings: 1st International Conference on Chemo and BioInformatics,","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.46793/iccbi21.060k","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Free Ph3Sn(CH2)nOH (n = 3, 4, 6, 8 and 11) and immobilized organotin(IV) compounds, SBA- 15~Cl|Ph3Sn(CH2)nOH, were prepared and tested against different tumor cell lines. Both compounds and nanomaterials revealed strong cytotoxic potential. SBA-15~Cl|Ph3Sn(CH2)3OH as well as free compound induce caspase triggered apoptosis in human ovarian A2780 cells. Ph3Sn(CH2)6OH and corresponding nanomaterial induced apoptosis in mouse melanoma B16 cells. Survived clones of B16 cells demonstrated phenotypic changes, they differentiate toward melanocytes.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
