{"title":"Synthesis, Characterization and Antimicrobial Activity of 2-[1-(2,4-Dihydroxyphenyl)Ethylene]Hydrazine Carboxamide and its Zn(II) Metal Complex","authors":"Ratnamala P. Sonawane","doi":"10.18052/WWW.SCIPRESS.COM/ILCPA.79.9","DOIUrl":null,"url":null,"abstract":"The synthesis of 2-[1-(2,4- dihydroxyphenyl)ethylene]hydrazinecarboxamide and its Zn(II) metal complex was achieved. 2, 4 dihydroxy acetophenone is synthesized by resorcinol with glacial acetic acid. This further treated with semicarbazide hydrochloride to form its semicarbazone. Zn(II) metal complex was prepared by dissolving equimolar quantities of metal salt and Schiff base ligand in ethanol. All the target compounds were characterized by M.P, TLC and UV-visible and IR spectral data. Antimicrobial activities of these synthesized compounds were studied in sterile saline by Agar well diffusion method against M. luteus, B. subtilis, S. aureus, E. coli, P. aeruginosa bacteria. All the synthesized compounds have shown good to moderate antimicrobial activity.","PeriodicalId":14453,"journal":{"name":"International Letters of Chemistry, Physics and Astronomy","volume":"573 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Letters of Chemistry, Physics and Astronomy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18052/WWW.SCIPRESS.COM/ILCPA.79.9","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
The synthesis of 2-[1-(2,4- dihydroxyphenyl)ethylene]hydrazinecarboxamide and its Zn(II) metal complex was achieved. 2, 4 dihydroxy acetophenone is synthesized by resorcinol with glacial acetic acid. This further treated with semicarbazide hydrochloride to form its semicarbazone. Zn(II) metal complex was prepared by dissolving equimolar quantities of metal salt and Schiff base ligand in ethanol. All the target compounds were characterized by M.P, TLC and UV-visible and IR spectral data. Antimicrobial activities of these synthesized compounds were studied in sterile saline by Agar well diffusion method against M. luteus, B. subtilis, S. aureus, E. coli, P. aeruginosa bacteria. All the synthesized compounds have shown good to moderate antimicrobial activity.
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