Cardioprotective Effect of Ethanolic Extract of Leaves of Amaranthus cruentus in Isoprenaline-Induced Myocardial Infarction in Rats

Free Radicals and Antioxidants Pub Date : 2020-08-25 DOI:10.5530/fra.2020.1.5

Priya Bisen, A. Chaturvedi, A. Ganeshpurkar, Nazneen Dubey

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Abstract

Cite this article: Bisen P, Chaturvedi A, Ganeshpurkar A, Dubey N. Cardioprotective Effect of Amaranthus cruentus Extracton Isoprenaline Induced Myocardial Infraction in Rats. Free Radicals and Antioxidants. 2020;10(1):23-8. ABSTRACT Objectives: The present study is focused to evaluate cardioprotective activity of ethanolic extract of Amaranthus cruentus. Methods: Amaranthus cruentus extract (Dose 200mg/kg and 400mg/kg) in isoprenaline induced myocardial infarction in rats. The ethanolic extract of Amaranthus cruentus was prepared and subjected to acute toxicity in albino rats. The extract was given orallyat two different doses 200mg/kg and 400mg/. Isoprenaline was administered subcutaneously (85mg/kg s.c.). Results: The histopathological examination revealed mild infarction and inflammation in isoprenaline treated rats. The ethanolic extract of Amaranthus cruentus showed significant cardio protective effect by decreasing the serum level of LDL and VLDL cholesterol levels. The biochemical parameters (AST, ALT and ALP) and HDL cholesterol levels were restored. Conclusion: The outcome of the present study suggested cardioprotective activity of Amaranthus cruentus extract.

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苋菜叶乙醇提取物对异丙肾上腺碱致大鼠心肌梗死的心脏保护作用

引用本文:毕森，杜贝，杜贝。异丙肾上腺素对大鼠心肌梗死的保护作用。自由基与抗氧化剂[j] . 2020;10(1):23-8。摘要目的:研究苋菜醇提物的心脏保护作用。方法:分别用200mg/kg和400mg/kg剂量的苋菜提取物对异丙肾上腺素致大鼠心肌梗死进行治疗。本文制备了苋菜乙醇提取物，并对其进行了急性毒性实验。以200mg/kg和400mg/ kg两种不同剂量口服提取物。异丙肾上腺素皮下注射(85mg/kg s.c)。结果:组织病理学检查显示异丙肾上腺素治疗后大鼠出现轻度梗死和炎症反应。苋菜乙醇提取物通过降低血清LDL和VLDL胆固醇水平显示出明显的心脏保护作用。生化指标(AST、ALT、ALP)和HDL胆固醇水平均恢复正常。结论:苋菜提取物具有一定的心脏保护作用。

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Free Radicals and Antioxidants

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