Infections in Transplanted Patients

Abstract

Solid-organ transplantation is a therapeutic option for many end-stage diseases. One of the most common complications in the post-transplant period are different kind of infections. They are caused by some bacterial pathogens such as Legionella spp., Nocardia spp., Salmonella spp. and Listeria monocytogenes, many viral agents – Cytomegalovirus /CMV/, Herpes simplex virus / HSV/, Varicella-zoster virus /VZV/, Epstein-Barr virus /EBV/, and more rarely – fungi and parasites. The onset of the signs and symptoms is essential for establishing the diagnosis – wound infections occur during the first 30 days after transplantation, opportunistic infections – 2 to 6 month later, and beyond 6 months, recipients suffer from the same infections distributed in the general community. Infections in solid-organ transplant recipients are global socio-medical problem, leading to prolonged hospital stay, significant financial losses and disability /and high mortality rate/ of the patients.