Treatment with a platelet‐activating factor receptor antagonist improves hemodynamics and reduces epinephrine requirements, in a lethal rodent model of anaphylactic shock
C. Tacquard, W. Oulehri, O. Collange, L. H. Garvey, S. Nicoll, N. Tuzin, B. Gény, P. Mertes
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引用次数: 13
Abstract
In some cases, anaphylactic shock (AS) is still lethal, despite rapid use of epinephrine. High doses of epinephrine are associated with severe complications. Platelet‐activating factor (PAF) is secreted in massive amounts during AS, and a high plasma level is correlated with increased AS severity.
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