The level of nitric oxide and arginase activity in patients with arterial hypertension and diabetes mellitus during COVID-19

O. Sklyarova, S. R. Mahiiovych, N. Denysenko, L. Kobylinska, Y. Sklyarov
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引用次数: 1

Abstract

The aim of this study was to assess the level of nitric oxide production and arginase activity in patients with arterial hypertension and type II diabetes mellitus during infection with SARS-CoV-2. The study groups included patients with arterial hypertension, patients with arterial hypertension combined with a severe course of COVID-19 and patients who, in addition to arterial hypertension and COVID-19, were suffering from type II diabetes mellitus. The volunteers without any clinical signs of diseases and normal blood pressure formed the control group. It has been established that arterial hypertension, combined with COVID-19 occurs along with reduced L-arginine, nitric oxide, superoxide dismutase activity and increased arginase activity. At the same time, the presence of arterial hypertension in patients with diabetes and coronavirus disease is accompanied by a decline in the content of L-arginine and arginase activity. Our study’s results may help scientists find new pharmacological targets in the future treatment of coronavirus disease and comorbid disorders. Keywords: arginase, COVID-19, diabetes mellitus, hypertension, L-arginine, nitric oxide, superoxide dismutase
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新冠肺炎期间动脉高血压合并糖尿病患者一氧化氮和精氨酸酶活性的变化
本研究的目的是评估动脉高血压和II型糖尿病患者在感染SARS-CoV-2期间一氧化氮生成水平和精氨酸酶活性。研究组包括动脉高血压患者、动脉高血压合并重症COVID-19患者以及除动脉高血压和COVID-19外合并2型糖尿病患者。无任何疾病临床症状、血压正常的志愿者为对照组。已经确定,动脉高血压合并COVID-19的发生伴随着l -精氨酸、一氧化氮、超氧化物歧化酶活性降低和精氨酸酶活性升高。同时,糖尿病和冠状病毒病患者动脉高血压的存在伴随着l -精氨酸含量和精氨酸酶活性的下降。我们的研究结果可能有助于科学家在未来治疗冠状病毒病和共病疾病中找到新的药理靶点。关键词:精氨酸酶,COVID-19,糖尿病,高血压,l -精氨酸,一氧化氮,超氧化物歧化酶
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