{"title":"Best practice and pitfalls in absolute structure determination","authors":"Anthony Linden","doi":"10.1016/j.tetasy.2017.07.010","DOIUrl":null,"url":null,"abstract":"<div><p>In routine small-molecule single crystal structure determination, accurate absolute structure determination has sometimes been challenging. Developments in diffractometers, X-ray sources, detectors and software, along with new concepts for the elucidation of the absolute structure have seen the greatest advances in recent times. Nonetheless, determining the absolute structure of a crystal, particularly when only light atoms are present, requires some thought in the planning of the experiment in order to obtain the best possible data and some care in modelling the structure and interpreting the results so as not to draw incorrect or unsupported conclusions. Some practical recommendations for best practice and how to avoid pitfalls and misinterpretations are presented as a guide, particularly for those new to the field of crystal structure analysis.</p></div>","PeriodicalId":22237,"journal":{"name":"Tetrahedron, asymmetry","volume":"28 10","pages":"Pages 1314-1320"},"PeriodicalIF":0.0000,"publicationDate":"2017-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tetasy.2017.07.010","citationCount":"8","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron, asymmetry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S095741661730352X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Chemistry","Score":null,"Total":0}
引用次数: 8
Abstract
In routine small-molecule single crystal structure determination, accurate absolute structure determination has sometimes been challenging. Developments in diffractometers, X-ray sources, detectors and software, along with new concepts for the elucidation of the absolute structure have seen the greatest advances in recent times. Nonetheless, determining the absolute structure of a crystal, particularly when only light atoms are present, requires some thought in the planning of the experiment in order to obtain the best possible data and some care in modelling the structure and interpreting the results so as not to draw incorrect or unsupported conclusions. Some practical recommendations for best practice and how to avoid pitfalls and misinterpretations are presented as a guide, particularly for those new to the field of crystal structure analysis.
期刊介绍：
Cessation. Tetrahedron: Asymmetry presents experimental or theoretical research results of outstanding significance and timeliness on asymmetry in organic, inorganic, organometallic and physical chemistry, as well as its application to related disciplines, especially bio-organic chemistry.
The journal publishes critical reviews, original research articles and preliminary communications dealing with all aspects of the chemical, physical and theoretical properties of non-racemic organic and inorganic materials and processes. Topics relevant to the journal include: the physico-chemical and biological properties of enantiomers; strategies and methodologies of asymmetric synthesis; resolution; chirality recognition and enhancement; analytical techniques for assessing enantiomeric purity and the unambiguous determination of absolute configuration; and molecular graphics and modelling methods for interpreting and predicting asymmetric phenomena. Papers describing the synthesis or properties of non-racemic molecules will be required to include a separate statement in the form of a Stereochemistry Abstract, for publication in the same issue, of the criteria used for the assignment of configuration and enantiomeric purity.
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