Tyler J. Rauwolf, Zhi Geng, Zachary P. Kinney, Jared Renfroe, Jack Roireau, Lauren Yep, R. Mohan
{"title":"Conjugate Addition of Indoles to α,β-Unsaturated Ketones Using Bismuth (III) Bromide","authors":"Tyler J. Rauwolf, Zhi Geng, Zachary P. Kinney, Jared Renfroe, Jack Roireau, Lauren Yep, R. Mohan","doi":"10.4236/GSC.2019.93005","DOIUrl":null,"url":null,"abstract":"An efficient method for the conjugate addition of \nindoles to a variety of chalcones using BiBr3 in ethanol (190 proof) \nis reported. Products are isolated by a simple procedure that avoids an aqueous \nwork up and extensive chromatography, thus minimizing waste. Bismuth (III) \ncompounds are especially attractive from a \ngreen chemistry perspective because they are remarkably nontoxic, \nnon-corrosive and relatively inexpensive.","PeriodicalId":12770,"journal":{"name":"Green and Sustainable Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Green and Sustainable Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4236/GSC.2019.93005","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
An efficient method for the conjugate addition of
indoles to a variety of chalcones using BiBr3 in ethanol (190 proof)
is reported. Products are isolated by a simple procedure that avoids an aqueous
work up and extensive chromatography, thus minimizing waste. Bismuth (III)
compounds are especially attractive from a
green chemistry perspective because they are remarkably nontoxic,
non-corrosive and relatively inexpensive.
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