Bioadhesive microspheres, II. Characterization and evaluation of bioadhesion involving hard, bioerodible polymers and soft tissue

Reactive Polymers Pub Date : 1995-06-01 DOI:10.1016/0923-1137(94)00098-P

D.E Chickering III, J.S Jacob, E Mathiowitz

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引用次数: 57

Abstract

Several bioerodible polymers and one hydrogel were studied as potential bioadhesive materials. A microbalance-based method was used to measure bioadhesive interactions between individual polymer microspheres and rat intestinal tissue. In addition, surface and bulk properties of these microspheres were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, and contact angle measurements. Polyanhydride microspheres composed of copolymers of fumaric and sebacic acid, produced bioadhesive fracture strengths greater than 50 mN/cm² with rat small intestinal mucosa in vitro. We suggest that bioadhesion in these bioerodible materials is not attributable to chain entanglement, but instead to hydrogen bonding between hydrophilic functional groups (COOH) and mucus glycoproteins. We also believe that continuous degradation of these materials may enhance their bioadhesive properties by changing surface energy, and increasing both carboxylic acid concentration and surface roughness.

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生物胶粘剂微球;涉及硬、生物可降解聚合物和软组织的生物粘附的表征和评价

研究了几种生物可降解聚合物和一种水凝胶作为潜在的生物粘附材料。采用基于微天平的方法测量了单个聚合物微球与大鼠肠道组织之间的生物粘附相互作用。此外，通过扫描电子显微镜、傅里叶变换红外光谱和接触角测量对这些微球的表面和体积性质进行了表征。由富马酸和癸二酸共聚物组成的聚酸酐微球在体外与大鼠小肠黏膜产生大于50 mN/cm2的生物粘接断裂强度。我们认为这些生物可降解材料中的生物粘附不是由于链缠结，而是由于亲水性官能团(COOH)和黏液糖蛋白之间的氢键。我们还认为，这些材料的持续降解可以通过改变表面能，增加羧酸浓度和表面粗糙度来增强其生物粘附性能。

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