{"title":"Synthesis and Biological Evaluation of Urea Derivatives of Combretastatins as Anticancer Agents","authors":"V. Ramesh, G. Rao, B. Chakrapani, A. Chakravarthy","doi":"10.7598/cst2018.1525","DOIUrl":null,"url":null,"abstract":"A series of new combretastatin urea derivatives (12a-j) were synthesized by reacting of substituted aromatic isocyanates (11a-j) to the combretastatin pyrazole-amine. The synthesized derivatives 11a-j were evaluated for their cytotoxicity against four human cancer cell lines (breast, lung and ovarian). Among them, compounds 12a, 12c, 12d, 12f, 12g and 12i were showed potent anticancer activity.","PeriodicalId":10087,"journal":{"name":"Chemical science transactions","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical science transactions","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7598/cst2018.1525","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
A series of new combretastatin urea derivatives (12a-j) were synthesized by reacting of substituted aromatic isocyanates (11a-j) to the combretastatin pyrazole-amine. The synthesized derivatives 11a-j were evaluated for their cytotoxicity against four human cancer cell lines (breast, lung and ovarian). Among them, compounds 12a, 12c, 12d, 12f, 12g and 12i were showed potent anticancer activity.
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