Molecular Docking Study of Several Antiviral Drugs to Defeat Covid-19

Abstract

Corona virus is one of the significant pathogens that destructs the human respiratory functioning Deaths and casualties caused by coronaviruses (CoVs) include the severe acute respiratory syndrome (SARS)-CoV and the Middle East respiratory syndrome (MERS)-CoV The aim of the work was to compare several antiviral drugs and find out which is the most active drug that might be used in treatment for COVID -19 In this study Molecular Docking approach was used to determine the binding affinities of 62 antiviral molecules The study was carried out using Molegro Virtual Docker 6 0 with PDB 2GTB procured from RCSB Protein Data Bank Simeprevir and Telaprevir were discovered to be most potent having high MolDock and Rerank scores of -225 158, -78 4383 and -209 467, -136 155 respectively Further studies may be conducted to design more potent analogue and defeat COVID-19