{"title":"Coupling Contraction-expansion Arrays with Spiral Microchannels to Enhance Microfluidic-Based Particle/Cell Separation","authors":"Z. Shahraki, M. Navidbakhsh, Robert A. Taylor","doi":"10.1080/10618562.2022.2053114","DOIUrl":null,"url":null,"abstract":"In the field of microfluidic inertial-based focusing of suspended particles, no research has been conducted to bring together two of the main directions of research, trapezoid spiral microchannels and contraction-expansion array (CEA)s. This paper addresses that gap by investigating two proposed CEAs (smooth and abrupt) inside a spiral channel compared to a uniform cross-section design at three different flow rates (i.e. 3, 6, and . The conservation equations of mass and momentum with a Lagrangian’-Eulerian (LE) approach are solved in OpenFOAM, using a four-way coupling between the phases. The results indicate that adding smooth transition CEAs to spiral microchannels, at a nominal flow rate , decreases the focusing duration (by about 29%) and the cell lysis probability (by about 52%) while keeping the separation efficiency high (nearly 100%). Overall, this study opens a promising new, integrated direction for passive microfluidic focusing of particles.","PeriodicalId":56288,"journal":{"name":"International Journal of Computational Fluid Dynamics","volume":"27 1","pages":"63 - 90"},"PeriodicalIF":1.1000,"publicationDate":"2022-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Computational Fluid Dynamics","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1080/10618562.2022.2053114","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MECHANICS","Score":null,"Total":0}
引用次数: 2
Abstract
In the field of microfluidic inertial-based focusing of suspended particles, no research has been conducted to bring together two of the main directions of research, trapezoid spiral microchannels and contraction-expansion array (CEA)s. This paper addresses that gap by investigating two proposed CEAs (smooth and abrupt) inside a spiral channel compared to a uniform cross-section design at three different flow rates (i.e. 3, 6, and . The conservation equations of mass and momentum with a Lagrangian’-Eulerian (LE) approach are solved in OpenFOAM, using a four-way coupling between the phases. The results indicate that adding smooth transition CEAs to spiral microchannels, at a nominal flow rate , decreases the focusing duration (by about 29%) and the cell lysis probability (by about 52%) while keeping the separation efficiency high (nearly 100%). Overall, this study opens a promising new, integrated direction for passive microfluidic focusing of particles.
期刊介绍：
The International Journal of Computational Fluid Dynamics publishes innovative CFD research, both fundamental and applied, with applications in a wide variety of fields.
The Journal emphasizes accurate predictive tools for 3D flow analysis and design, and those promoting a deeper understanding of the physics of 3D fluid motion. Relevant and innovative practical and industrial 3D applications, as well as those of an interdisciplinary nature, are encouraged.
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