Comparative study between topical clotrimazole manufactured by nanotechnology alone and with neodymium‐doped yttrium aluminum garnet laser (1064 nm) compared with neodymium‐doped yttrium aluminum garnet laser alone in the treatment of onychomycosis

Wafaa Eid, Faten Aabdelkawy, Asmaa M.Elbakry, Marwa Said
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Abstract

Background Onychomycosis is defined as a fungal infection of the nail. It is caused by dermatophytes, nondermatophytes, and yeasts. Nanosuspension is defined as a submicron colloidal dispersion of any of the drug particles. Neodymium‐doped yttrium aluminum garnet (Nd : YAG) laser has been reported to be effective for treating onychomycosis. The aim was to compare topical clotrimazole-loaded gel alone and with Nd : YAG laser compared with Nd : YAG laser only in patients with mycologically proven onychomycosis. Patients and methods A total of 60 patients presented with onychomycosis. All patients were subjected to a full history taking, dermoscopic and clinical examination, assessment of severity by using the onychomycosis severity index, and culture. Results There was a statistically significant response (decrease in onychomycosis severity index, dermoscopic features, and mycological clearance) in patients treated by both topical clotrimazole and Nd : YAG laser compared with laser alone or topical clotrimazole-loaded gel alone. Conclusion Clotrimazole-loaded gel showed high efficacy against Candida and can be used as an adjuvant to systemic or topical antifungal treatment for onychomycosis or laser system.
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纳米技术制备的局部克霉唑与掺钕钇铝石榴石激光(1064 nm)治疗甲癣的比较研究与单独掺钕钇铝石榴石激光的比较
甲真菌病被定义为指甲的真菌感染。它是由皮肤真菌、非皮肤真菌和酵母引起的。纳米悬浮液被定义为任何药物颗粒的亚微米胶体分散体。据报道,掺钕钇铝石榴石(Nd: YAG)激光治疗甲癣是有效的。目的是比较单独局部负载克霉唑凝胶和Nd: YAG激光与Nd: YAG激光在真菌学证实的甲癣患者中的疗效。患者与方法共60例甲真菌病患者。所有患者均接受完整的病史记录、皮肤镜和临床检查、使用甲癣严重程度指数评估严重程度和培养。结果与单独使用激光或单独使用克霉唑凝胶相比,局部使用克霉唑和Nd: YAG激光治疗的患者有统计学意义的缓解(甲癣严重指数、皮肤镜特征和真菌学清除率降低)。结论氯霉唑凝胶对念珠菌具有良好的抗真菌效果,可作为全身或局部治疗甲癣或激光系统的辅助药物。
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