Hypopigmented mycosis fungoides in Saudi Arabia, epidemiological and pathological study

Ahmed A. Alhumidi
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引用次数: 2

Abstract

Introduction

Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma. Hypopigmented MF is one of the less common variants of MF. Although rare, the exact frequency of HMF is still unknown.

Materials and methods

We performed a retrospective review of 17 cases of hypopigmented mycosis fungoides at two major tertiary centers in Saudi Arabia from the period 2010–2013. We described the clinical and important histological features of these cases. CD3, CD4, CD8, and CD7 stains performed for these cases have also been reviewed.

Results

There were 5 male and 11 female patients. The age of onset of disease ranged between 5 and 60 with a mean of 17 years. All the patients presented with hypopigmented scaly patches. Most common sites of distribution of the lesions were upper and lower extremities (100%) then the trunk (76%). The presence of lymphocytes at the dermoepidermal junction was the most frequent finding seen in 100% cases. Basilar predilection of the lymphocytes was seen in 75.5%. CD8 positivity in epidermal and dermal lymphocytes was seen in 14/17 biopsies. Focal positivity CD4 of the dermal lymphocytes was evident in 5/17. Loss of CD7 is noted in 14/17 biopsies.

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沙特阿拉伯低色素真菌病的流行病学和病理学研究
真菌样真菌病(MF)是最常见的皮肤t细胞淋巴瘤。低色素性MF是一种较不常见的MF变型。虽然罕见,但HMF的确切频率仍然未知。材料和方法我们对2010-2013年期间沙特阿拉伯两个主要三级中心的17例低色素蕈样真菌病进行了回顾性分析。我们描述了这些病例的临床和重要的组织学特征。这些病例的CD3、CD4、CD8和CD7染色也已被回顾。结果男性5例,女性11例。发病年龄在5岁至60岁之间,平均17岁。所有患者均表现为低色素的鳞状斑块。病变最常见的分布部位为上肢和下肢(100%),其次为躯干(76%)。淋巴细胞在真皮表皮交界处的存在是最常见的发现,在100%的病例中可见。75.5%为基底淋巴细胞偏爱。14/17活检中表皮和真皮淋巴细胞CD8阳性。5/17例真皮淋巴细胞局灶性CD4阳性。14/17的活组织检查发现CD7缺失。
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发文量
17
审稿时长
16 weeks
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