Hanna Reuter , Johannes Krug , Peter Singer , Christoph Englert
{"title":"The African turquoise killifish Nothobranchius furzeri as a model for aging research","authors":"Hanna Reuter , Johannes Krug , Peter Singer , Christoph Englert","doi":"10.1016/j.ddmod.2018.12.001","DOIUrl":null,"url":null,"abstract":"<div><p><em>Nothobranchius furzeri</em> is an African killifish with an exceptionally short median life span of 3 to 7 months. Despite its short life span <em>N. furzeri</em> displays signs of aging that are highly reminiscent of mammalian aging. In 2015, reference sequences for the <em>N. furzeri</em> genome have been published. In addition, transgenesis and genomic engineering of killifish using CRISPR/Cas9 have been recently established. It has also been shown that <em>N. furzeri</em> is amenable to pharmacologic intervention. In this review we will discuss what makes <em>N. furzeri</em> a valuable model for research on aging and whether it could also be used for drug discovery.</p></div>","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":"27 ","pages":"Pages 15-22"},"PeriodicalIF":0.0000,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmod.2018.12.001","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Discovery Today: Disease Models","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1740675718300057","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 9
Abstract
Nothobranchius furzeri is an African killifish with an exceptionally short median life span of 3 to 7 months. Despite its short life span N. furzeri displays signs of aging that are highly reminiscent of mammalian aging. In 2015, reference sequences for the N. furzeri genome have been published. In addition, transgenesis and genomic engineering of killifish using CRISPR/Cas9 have been recently established. It has also been shown that N. furzeri is amenable to pharmacologic intervention. In this review we will discuss what makes N. furzeri a valuable model for research on aging and whether it could also be used for drug discovery.
期刊介绍：
Drug Discovery Today: Disease Models discusses the non-human experimental models through which inference is drawn regarding the molecular aetiology and pathogenesis of human disease. It provides critical analysis and evaluation of which models can genuinely inform the research community about the direct process of human disease, those which may have value in basic toxicology, and those which are simply designed for effective expression and raw characterisation.
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