Depressed Prostaglandin Release from Peritoneal Cells Induced by a T Cell Adjuvant, Lentinan

Abstract

PGE and PGF release from peritoneal exudate cells was studied in mice after injection with two ß (1–3) glucans, the antitumor active lentinan and the inactive pachyman. 4 days after injection of both polysaccharides, the spontaneous and phagocytosis-induced PGE and PGF release was markedly suppressed. However, only the immunopotentiator lentinan induced peritoneal exudate cells which exhibited a longer lasting diminished PG release. The data suggest that the T cell adjuvant lentinan may potentiate cellular immune responses by reducing synthesis of immune suppressive prostaglandins from peritoneal exudate cells.