Spontaneous remission of acute myeloblastic leukemia with improvement in CD4 counts in HIV-infected child co-infested with Demodex mite

Pediatric Infectious Disease Pub Date : 2015-10-01 DOI:10.1016/j.pid.2015.10.006

Jitendra Kumar, Anand Kumar Gupta, Gagandeep Singh, Pratibha Kale, Immaculata Xess, Rachna Seth, Aparna Mukherjee, Rakesh Lodha, S.K. Kabra

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引用次数: 1

Abstract

Improvement in CD4 counts in children with human immunodeficiency virus (HIV) has been reported with some infections. We present an 11-year-old HIV-infected boy who developed acute myeloid leukemia that showed spontaneous remission along with improvement in CD4 counts with documented Demodex mite infestation. The child presented with fever without localization during course of illness, and developed crusted lesion at angle of mouth. Direct microscopy of skin biopsy revealed Demodex mite infestation. The child was continued on highly active antiretroviral treatment along with single dose of ivermectin and local application of permethrin. The crusted lesion improved within a weeks’ time. His CD4 counts improved from baseline of 534/μL to 1674/μL over a period of 4 weeks.

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与蠕形螨共感染的hiv感染儿童的CD4计数改善急性髓母细胞白血病的自发缓解

据报道，一些感染人类免疫缺陷病毒(HIV)的儿童CD4计数有所改善。我们报告了一名11岁的hiv感染男孩，他患上了急性髓性白血病，随着CD4计数的改善和记录的蠕形螨感染，他表现出自发缓解。患儿在发病过程中有发热无定位，口角出现结痂性病变。皮肤活检直接镜检显示蠕形螨感染。患儿继续接受高效抗逆转录病毒治疗，同时给予单剂量伊维菌素和局部应用氯菊酯。结痂病变在一周内得到改善。在4周的时间里，他的CD4计数从基线的534/μL提高到1674/μL。

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Pediatric Infectious Disease

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