Lipid Profile Abnormalities and Their Association with Covid-19 Severity among Patients Admitted at Covid-19 Center in Ethiopia

Y. G. Tsegay, M. Bitew, Assegdew Atlaw, Mintsnot Aragaw, Shambel Araya, Mesay Gemechu, Nega Brhane, Tigist Workneh
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Abstract

Background: Current studies have presented and analyzed epidemiological, clinical and clinical laboratory features COVID-19 Patients. Studies suggests that patients with severe COVID-19 shows unregulated lipid metabolism and profile but adequate information is not available concerning the association of lipid parameter features with severity of disease its outcome in Ethiopia. Objective: This study aims to determine the magnitude of lipid profile abnormalities and association of COVID-19 outcome among admitted patients at Millennium COVID-19 care center in Ethiopia. Methods: A prospective observational cohort study was conducted among COVID-19 admitted patients to investigate lipid profile parameters from January 2021- June 2021. A total of 500 patients confirmed with COVID-19 infection by RT-PCR were included. Dynamic alteration in lipid profiles were recorded and tracked. Data were analyzed using SPSS version 25. P value <0.05 was considered significantly associated. Result: The median age of the 500 study participants was 55.58+7.707 years, and from these 71.3% of patients were males. This study found that high-density Lipoprotein cholesterol (HDL-C) and Total Cholesterol levels were significantly higher in the severe and Critical disease category. The total cholesterol results showed that significantly higher 25 (5.38%) in severe infection cases than that, (17 (3.4%), 12(2.4%) and 5 (1%) in moderate, mild and critical cases consecutively (P<0.000). Whereas, patients with severe infection had slightly lower of HDL than Mild and moderate infection cases (P=0.000 and P=0.000) respectively. Moreover, a significant decrement in the level of TG was detected in severe infection cases compared to mild and moderate cases (P=0.0001). Hence, the higher TG/HDL-C ratio (3.754) was found in severe infection cases, compared with mild and moderate infection (P=0.001 and P=0.002) respectively. Conclusion: Lipid function biomarkers like CHO, TG and LDL serum value was found elevated among severe than other patients. Lipid Metabolism biomarkers are a candidate for predicting COVID-19 disease severity in order to guide clinical care and general Public
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埃塞俄比亚Covid-19中心入院患者的血脂异常及其与Covid-19严重程度的关系
背景:目前的研究已经介绍并分析了COVID-19患者的流行病学、临床和临床实验室特征。研究表明,严重的COVID-19患者表现出不受调节的脂质代谢和特征,但在埃塞俄比亚,关于脂质参数特征与疾病严重程度及其结果之间的关系,没有足够的信息。目的:本研究旨在确定埃塞俄比亚千年COVID-19护理中心入院患者的血脂异常程度及其与COVID-19结局的关联。方法:对2021年1月至2021年6月入院的COVID-19患者进行前瞻性观察队列研究,调查血脂参数。共纳入500例经RT-PCR确诊的COVID-19感染患者。记录和跟踪脂质谱的动态变化。数据分析采用SPSS version 25。P值<0.05认为有显著相关性。结果:500名研究参与者的中位年龄为55.58+7.707岁,其中71.3%的患者为男性。该研究发现,高密度脂蛋白胆固醇(HDL-C)和总胆固醇水平在严重和危重疾病类别中显著较高。总胆固醇结果显示,重度感染组25例(5.38%)、中度感染组17例(3.4%)、轻度感染组12例(2.4%)、危重感染组5例(1%),差异均有统计学意义(P<0.000)。重度感染患者的HDL水平略低于轻度和中度感染患者(P=0.000和P=0.000)。此外,与轻度和中度感染病例相比,重度感染病例的TG水平显著下降(P=0.0001)。因此,重度感染患者的TG/HDL-C比值(3.754)高于轻度和中度感染患者(P=0.001和P=0.002)。结论:重症患者血脂功能指标CHO、TG、LDL均高于其他患者。脂质代谢生物标志物是预测COVID-19疾病严重程度的候选物,以指导临床护理和公众
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