The association between hypoxia, chronic ischemia and alters prostate structure and progress of chronic prostatic disease

Abstract

Chronic prostatitis today shows high level of relapses and recurrent pathological events even if using the best pharmacological therapy. A better understanding of physiopathological effect of ischemic hypoxic condition (pelvic, prostate tissue) and the lymphatic congestion in same body region contribute in evolution of a complex condition. The same focusing the strategy in biofilm reduction or in leukocyte infiltration can be a right way to reduce relapses and progression of the prostatic disease. Hypoxia is also related to prostatic cancer progression and prostatic biofilm if responsible of making a new microenvironment often drug resistance. A deep knowledge in this kind of phenomena can improve the clinical effect of drug therapy.